There are different ages of onset for all the LSDs. There are the neonatal ones, the infantile ones, the early childhood, the late childhood and the later onset in adolescence and adulthood. Most of these have some neurological abnormalities associated to them. In order to come up with the right one you have to associate that neurological defect with the other associated features, whether it’s bones, organs or hematological or cardiac to come up with the right diagnosis.