Finally, symptomatic treatments:  Apart from the disease treatment targeting the specific defects that led to the disease, pediatricians can also use symptomatic treatment to treat all these other complaints that the patient may have, in terms of pains, in terms of seizures and in terms of thrombocytopenia, anemia. They can use analgesics, anticonvulsants, opiates, antacids, orthopaedic options for all these bone deformities.  Sleep disturbances can be prominent in some of these patients so they can treat them for sleep disturbances, and palliative care for those LSDs that have a devastating neurological outcome.